Clinical Studies of Pueraria Mirifica
Source: The Medical Plant Research Institute Department of Medical Sciences, Ministry of Public Health Thailand . The Pueraria Mirifica is commonly found abundantly in the forested areas of the North, North East and West of Thailand. The active principles in the plant are located at the interconnected tuberous roots, which are similar to chains of round-shaped bulbs. The size and shape of the tuberous roots are varied and typically depend on the type of environment in which they are found.
The genus Pueraria Mirifica encompasses nine species of plants, which naturally look the same. The authenticity of the Pueraria Mirifica, however, can be verified through the distinct traits of the flower’s stamen and hairy pod.
This tuber plant is known to enlarge and gather at least thirteen (13) natural chemicals classified as PHYTOESTROGENS, which include: daidzein, miroestrol, B-sitosterol, genistin, stigmasterol, genistein, coumestrol, compesterol, mirificin, pueraria, kwakhurin, and mirificoumestan.
The miraculous rejuvenating properties of the Pueraria Mirifica have been passed down from generation to generation in the East.
Furthermore, the Pueraria Mirifica produces a rhizome extract, which contains the phytoestrogens or the hormone chemicals. The extract comprises mostly of isoflavones (daidzein, genistin, daidzin, genistein and puerarin) and other chemicals, such as: beta-sitosterol, stigmasterol, puerarin, coumestrol, kwakhurin, mirificoumestan, b-sitosterol, mirificin, fat, alkane alcohol and sugar.
The Pueraria Mirifica has also been reported to contain the estrogenic component miroestrol, which can be found in the plant’s dry rhizome in amounts of about 0.002-0.003 percent. This estrogenic substance has been proven to be more effective than the estrogen produced by the human body.
The phytoestrogen components of Pueraria Mirifica are capable of imitating human female estrogen to provide likely results.
Studies, which involved breast cell lines and Pueraria Mirifica’s activity in vitro, have been executed by the Emory University School of Medicine located at Atlanta , Georgia , USA . Accompanying research centers include Thailand ’s Phramongkutklao College of Medicine and Department of Obstetrics and Gynecology. Their studies revealed that the plant’s root extract has potent anti-estrogenic properties against aggressive cancer cell lines in vitro, especially the proliferative ER+ or estrogen receptor-positive breast cancer lines (MCF-7, T47-D and ZR-75-1) obtained from the National Cancer Institute of the U.S. NIH and the MD Anderson Cancer Institute. The Pueraria Mirifica helps promote fibroblasts in normal breast cells and inhibit breast cancer cells that are estrogen-dependent. Unpublished, 2001, Jitpatima, S., Sawatsri, S., Boonnao, P., Juntayanee, B., Ayuttaya N., Kampoo, C., Sidell, N., and Wongyai, S.
According to the study carried out at the School of Medicine at Saint Mariane University or Tokyo , Japan , by Smitasiri, Y., and Kuramoshi, T. regarding the initial Peuraria Mirifica study in Japanese females, around 50 healthy and menstruating volunteers, aged 20- 49, were given Pueraria Mirifica root power daily as capsule for one week, exactly two weeks after menstruation. The dosage was about 100 to 600 mg and taken orally. There were no reports of severe, missed or heavy menstruation.
Animal Test: During the year 1960-61, there were reports from the British researchers about the effects of miroestrol, the key component of the plant, to the premature and ovariectomized female rats. The report showed that effects of the chemical, which stated that the animal or even human estrogen can be safely substituted by the chemical.
Human Test: The root of Pueraria Mirifica has also been tested in humans and was reported in the year 1961. It showed the plant to have effective estrogen effect. The medical doctors of Thailand have tested the crude extract from the plan in patients in 1941. The results were also promising.